Nanoparticle technology is bringing changes and modifications to the way we do medicine.
Lately, we have heard a lot about this technology bringing innovation to vaccinations.
Nanomedicine is a term usually used for the medical application of nanoparticle technology.
Nanotechnology in medicine improves medicines’ action.
Furthermore, nanomedicine enables the design of biological machines and Nano-electronic biosensors.
Nanomedicine has led to the development of diagnostic devices, contrast agents, and analytical tools.
For today’s purpose, let’s focus on vaccines because this is our biggest threat as we speak.
Let’s start with this paper:
“Nanoparticles for nasal vaccination.”
The authors state:
“The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens. Among other mucosal sites, nasal delivery is especially attractive for immunization, as the nasal epithelium is characterized by relatively high permeability, low enzymatic activity and by the presence of an important number of immunocompetent cells.”
“In addition to these advantageous characteristics, the nasal route could offer simplified and more cost-effective protocols for vaccination with improved patient compliance.”
The use of nanocarriers provides a suitable way for the nasal delivery of antigenic molecules. Besides improved protection and facilitated transport of the antigen, nanoparticulate delivery systems could also provide more effective antigen recognition by immune cells. These represent key factors in the optimal processing and presentation of the antigen, and therefore in the subsequent development of a suitable immune response. In this sense, the design of optimized vaccine nanocarriers offers a promising way for nasal mucosal vaccination.”
This paper was published 11 years ago! They have been working on this for a very long time.
I understand the concept of this new route of vaccine delivery, but on the other side, we have no idea when it is being done. Any nasal swab could potentially deliver any vaccine to us…
The second paper is:
“Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery.”
The researchers mention:
“ Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations.”
“Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption.”
This article goes over the fact that anything delivers into the nasal cavities is rapidly cleared by our immune system. Thus, scientists had to come up with a way to bypass this issue: the hydrogel nanosystem is the answer.
Finally, this article:
“Nasal vaccine innovation.”
The authors wrote:
“The current vaccine market is gaining momentum in the development of alternative administration routes, namely intranasal, oral, topical, pulmonary, vaginal, and rectal; the nasal route offers the most promising opportunity for vaccine administration.”
“Nasal vaccine innovation comes with both opportunities and challenges. The innovative strategies used by industry and researchers to overcome the hurdles are discussed in this article: these include live-attenuated vaccines, adjuvants, mucoadhesives, particulate delivery systems, virus-like particles, vaccine manufacture, challenges of regulatory authorities, and the nasal vaccine impact on market potential.”
“Critical issues for effective nasal vaccination are the antigen-retention period that enables its interaction with the lymphatic system and choice of an adjuvant that is nontoxic and induces the required immune response.”
“Co-adjuvanting by means of a mucoadhesive technology addresses some of these issues. ChiSys®, a natural bioadhesive with proven intranasal safety profile, has already demonstrated efficacy for several nasally delivered vaccines including norovirus. With the looming threat of a pandemic, alternatives such as intranasal vaccination will ultimately facilitate greater public compliance and rapid mass global vaccination.”
This confirms that the technology is already here and most likely being used.
It is funny to me when they mention that adjuvants are nontoxic. There is no such thing as nontoxic adjuvants. They all have been shown to cause damage to the body.
The concern that I am currently having is all those nasal swabs that have been used for the coronavirus diagnostic test, were they nasal vaccines?
I believe this is a legit question as I have repeatedly heard people getting sick after they did the test, which raises suspicion…
My recommendation: avoid those nasal swabs. We do not know why they do them because the test by itself is up to 90% nonspecific.
God bless y’all 😊